Sublingual vaccination
نویسندگان
چکیده
منابع مشابه
Immunity of Foot-and-Mouth Disease Serotype Asia 1 by Sublingual Vaccination
Foot-and-mouth disease virus (FMDV) causes vesicular disease of cloven-hoofed animals, with severe agricultural and economic losses. Here we present study using a sublingual (SL) route with the killed serotype Asia 1 FMDV vaccine. Guinea pigs were vaccinated using a commercially available vaccine formulation at the manufacturer's recommended full, 1/4, and 1/16 antigen doses. Animals were chall...
متن کاملCCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination.
Our previous studies demonstrated the potential of the sublingual (s.l.) route for delivering vaccines capable of inducing mucosal as well as systemic immune responses. Those findings prompted us to attempt to identify possible inductive mechanism of s.l. vaccination for immune responses. Within 2 h after s.l. administration with cholera toxin (CT), significantly higher numbers of MHC class II(...
متن کاملEfficacy of sublingual allergen vaccination for respiratory allergy in children. Conclusions from one meta-analysis.
BACKGROUND Sublingual route, that allows the safe administration of allergen vaccination at home and without injections, is a highly attractive alternative to parenteral delivery, especially among the youngest population. However, its efficacy in children has been questioned. OBJECTIVE To evaluate the efficacy (symptom and medication scores) of sublingual allergen vaccination compared to plac...
متن کاملSublingual Vaccination Induces Mucosal and Systemic Adaptive Immunity for Protection against Lung Tumor Challenge
Sublingual route offers a safer and more practical approach for delivering vaccines relative to other systemic and mucosal immunization strategies. Here we present evidence demonstrating protection against ovalbumin expressing B16 (B16-OVA) metastatic melanoma lung tumor formation by sublingual vaccination with the model tumor antigen OVA plus synthetic glycolipid alpha-galactosylceramide (aGal...
متن کاملSublingual vaccination with influenza virus protects mice against lethal viral infection.
We assessed whether the sublingual (s.l.) route would be an effective means of delivering vaccines against influenza virus in mice by using either formalin-inactivated or live influenza A/PR/8 virus (H1N1). Sublingual administration of inactivated influenza virus given on two occasions induced both systemic and mucosal antibody responses and conferred protection against a lethal intranasal (i.n...
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ژورنال
عنوان ژورنال: Human Vaccines
سال: 2011
ISSN: 1554-8600,1554-8619
DOI: 10.4161/hv.7.1.13739